The womb determines the autism/downs

(http://www.autoadmit.com/thread.php?thread_id=3495190&forum_id=2],#44155918)

(http://www.autoadmit.com/thread.php?thread_id=3495190&forum_id=2],#32955569)

In their analysis, the researchers identified and controlled for other age-related influences that might affect autism risk. When separating the influence of mother’s versus father’s age, they also adjusted for the potential influence of the other parent’s age.

“After finding that paternal age, maternal age and parental-age gaps all influence autism risk independently, we calculated which aspect was most important,” Dr. Sandin adds. “It turned out to be parental age, though age gaps also contribute significantly.”

Specifically the study found:

* Autism rates were 66 percent higher among children born to dads over 50 years of age than among those born to dads in their 20s. Autism rates were 28 percent higher when dads were in their 40s versus 20s.

* Autism rates were 18 percent higher among children born to teen moms than among those born to moms in their 20s.

* Autism rates were 15 percent higher in children born to mothers in their 40s, compared to those born to moms in their 20s

* Autism rates rose still higher when both parents were older, in line with what one would expect if each parent’s age contributed to risk.

* Autism rates also rose with widening gaps between two parents’ ages. These rates were highest when dads were between 35 and 44 years old and their partners were 10 or more years younger. Conversely, rates rose when moms were in their 30s and their partners were 10 or more years younger.

The higher risk associated with fathers over 50 is consistent with the idea that genetic mutations in sperm increase with a man’s age and that these mutations can contribute to the development of autism. By contrast, the risk factors associated with a mother’s age remain unexplained, as do those associated with a wide gap between a mother and father’s age.

“These results suggest that multiple mechanisms are contributing to the association between parental age and ASD risk,” the authors conclude.

“When we first reported that older age of fathers increases risk for autism, we suggested that mutations might be the cause,” notes co-author Abraham Reichenberg. “Genetic research later showed that this hypothesis was correct. In this study, we show for the first time that autism risk is associated with disparately aged parents. Future research should look into this in order to understand the mechanisms.” Dr. Reichenberg is a neuropsychologist and epidemiologist with the Icahn School of Medicine at Mount Sinai, in New York City.

Such answers are among the goals of the Autism Speaks MSSNG project (pronounced "missing"). MSSNG, the world's largest autism whole genome sequencing initiative, is providing the autism research community with the genomic data and tools needed to find the causes and potential individualized treatments of autism. Learn more about MSSNG here.

https://www.autismspeaks.org/science/science-news/large-study-parent-age-autism-finds-increased-risk-teen-moms

(http://www.autoadmit.com/thread.php?thread_id=3495190&forum_id=2],#32955573)

Paternal age has the greater effect. OP's thread clearly implies 41 year old is a woman rather than a dude.

Anyway, 40+ is pretty fucking old for either men or women to have kids. Xoxo likes to ignore the fact that affects men as well.

(http://www.autoadmit.com/thread.php?thread_id=3495190&forum_id=2],#32955797)

Lots of kids, don't feel a need to say words until later. Can think of lots of examples of friends' children who experienced a language explosion btwn 2 and 3. Boys tend to speak later. And one day they just start talking and don't shut up. By 3 would be a cause for concern.

(http://www.autoadmit.com/thread.php?thread_id=3495190&forum_id=2],#32955751)

Julia's kid

(http://www.autoadmit.com/thread.php?thread_id=3495190&forum_id=2],#35962728)