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Disappearing polymorphs are fucking crazy

https://en.wikipedia.org/wiki/Disappearing_polymorph
Bistre stead
  07/10/26
When the patent for paroxetine anhydrate (the "original...
Bistre stead
  07/10/26
Someone has never read Cat's Cradle
Khaki ticket booth idiot
  07/10/26
True But even if I had, I don't think a sci-fi novel woul...
Bistre stead
  07/10/26
I read about that for like two minutes yesterday and it did ...
geriatric lascivious range friendly grandma
  07/10/26


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Date: July 10th, 2026 8:01 PM
Author: Bistre stead

https://en.wikipedia.org/wiki/Disappearing_polymorph

(http://www.autoadmit.com/thread.php?thread_id=5881625&forum_id=2#49991956)



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Date: July 10th, 2026 8:04 PM
Author: Bistre stead

When the patent for paroxetine anhydrate (the "original" polymorph) ran out, other companies wanted to make generic antidepressants using the chemical. The problem was that, by the time other companies began manufacturing, Earth's atmosphere was already seeded with microscopic quantities of paroxetine hemihydrate from GSK's manufacturing plants, which meant that anyone trying to manufacture the original polymorph would find it transformed into the still-patented version, which GSK refused to give manufacturing rights for.

(http://www.autoadmit.com/thread.php?thread_id=5881625&forum_id=2#49991965)



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Date: July 10th, 2026 8:16 PM
Author: Khaki ticket booth idiot

Someone has never read Cat's Cradle

(http://www.autoadmit.com/thread.php?thread_id=5881625&forum_id=2#49991997)



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Date: July 10th, 2026 9:06 PM
Author: Bistre stead

True

But even if I had, I don't think a sci-fi novel would get me to think that 'planetary contamination of pharmaceutical dust can prevent less stable crystal structures from ever being made again' was a realistic conceit

(http://www.autoadmit.com/thread.php?thread_id=5881625&forum_id=2#49992103)



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Date: July 10th, 2026 9:08 PM
Author: geriatric lascivious range friendly grandma

I read about that for like two minutes yesterday and it did seem pretty crazy

(http://www.autoadmit.com/thread.php?thread_id=5881625&forum_id=2#49992106)